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Jurnalis on Wednesday, May 18, 2011
Overview of the role
Hypoxia is a key component of cancer pathology, and a wide range of cardiac, pulmonary, vascular and inflammatory diseases.
The hypoxia biology laboratory has discovered a series of enzymatic oxygen sensors that regulate transcriptional responses to hypoxia by post-translational hydroxylation of specific prolyl and asparaginyl residues in the transcription factor, hypoxia inducible factor (HIF) (1-3).
These oxygen sensors belong to a family of enzymes known as 2-oxoglutarate-dependent dioxygenases. Although several members of this family have been implicated in human disease, the roles they play in hypoxia signalling and pathological processes in vivo remains elusive. To facilitate discoveries in this area we aim to develop a generic transgenic vector for shRNA knockdown of 2-oxoglutarate-dependent dioxygenases.
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Jurnalis on Tuesday, May 17, 2011
Postdoctoral Scientist
Division of Developmental Neurobiology
We are recruiting for a 3-year Postdoctoral position within the National Institute for Medical Research. Our laboratory studies molecular and cellular mechanisms regulating development and maintenance of midbrain dopaminergic neurons. Research topics include deciphering gene regulatory networks involved in the specification and differentiation of these neurons. These projects utilize
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Jurnalis
We are looking to recruit up to five Postdoctoral scientists to work with Dr Jason Chin. The successful candidates will join Dr Chin’s expanding research programme, which includes the new Centre for Chemical & Synthetic Biology (CCSB). The postholders will develop and apply methods to genetically encode new amino acids in proteins. For recent examples see: A Gautier et al. J.Am Chem . Soc. 2010, H. Neumann et al. Mol. Ce11.2009, & Neumann et al Nature 2010.
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Jurnalis on Saturday, May 14, 2011
Post Doctoral Scientist
We are recruiting for a 3-year Postdoctoral position within the National Institute for Medical Research. The position involves the development of theoretical models of protein evolution with applications to fundamental biological topics such as speciation and host-pathogen co-evolution.
Applicants should have a PhD or equivalent in evolutionary biology, molecular biophysics, or related fields.
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Jurnalis on Wednesday, April 20, 2011
Postdoctoral Scientist – Stem Cell Biology at Paterson Institute for Cancer Research UK
A three year position, is available in the laboratory of Dr Georges Lacaud to study the molecular and cellular mechanisms of early haematopoietic development. In this context, we are focusing on the function of the transcription factor AML1/Runx1, a master regulator of haematopoietic development but also a frequent target of gene rearrangements and mutations in human leukemia. The in vitro differentiation system based on mouse embryonic stem (ES) cells and in vivo approaches will be used. Our ultimate goal is to use either ES cell differentiation or epigenetic reprogramming to generate transplantable blood cell populations. Selected references: Lancrin et al., (2009) Nature. Sroczynska et al.,(2009) Blood.
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Jurnalis on Tuesday, April 12, 2011
The Fraunhofer Institute for Cell Therapy and Immunology is one of 60 institutes of the Fraunhofer-Gesellschaft. As one of the leading organizations for applied research in Europe it offers ambitious scientists challenging tasks coupled with responsibility and room for creativity.
At the Fraunhofer Institute for Cell Therapy and Immunology in Leipzig, Germany a position is immediately available:
Postdoctoral scientist (f/m) in molecular biology
The Fraunhofer IZI is coordinating a large collaborative project that aims at the identification and validation of biomarkers on the basis of the non-protein coding part of the human genome. The project focuses on diagnostic and prognostic questions of utmost relevance for patients and health economy. Participation of five Fraunhofer Institutes from different technical and biomedical disciplines make this an outstanding highly interdisciplinary project striving to redefine the process of biomarker development.
